Italian Sub Grilled Cheese

Featured in: Oven & Skillet Basics

This Italian Sub Grilled Cheese brings together classic Italian-American flavors in a perfectly grilled sandwich. Layers of salami, pepperoni, and provolone are topped with a tangy lettuce mixture dressed in mayonnaise, red wine vinegar, and oregano, then grilled until the bread is golden and the cheese melts beautifully.

Ready in just 20 minutes with easy preparation, this satisfying main dish yields two hearty servings. The combination of savory cured meats and creamy provolone creates an authentic deli-style experience that's equally at home on a weeknight dinner table or at a casual gathering.

Updated on Wed, 21 Jan 2026 11:02:00 GMT
Golden-brown Italian Sub Grilled Cheese sandwiches sliced in half, revealing layers of melted provolone, salami, pepperoni, and tangy lettuce topping on a rustic board.  Save
Golden-brown Italian Sub Grilled Cheese sandwiches sliced in half, revealing layers of melted provolone, salami, pepperoni, and tangy lettuce topping on a rustic board. | dailyhlib.com

The rain was hammering against my kitchen window last Tuesday when I craved something that felt like a hug but had enough crunch to keep me interested. I had half a loaf of Italian bread staring back at me and a deli container of cold cuts from the weekend. That is when it hit me. Why not turn my Italian sub obsession into the ultimate grilled cheese?

My roommate walked in mid flip and actually stopped dead in her tracks. The smell of melting provolone and salami hitting that hot butter is not something anyone can ignore. We ate them standing up at the counter and neither of us said a word for five straight minutes.

Ingredients

  • Italian bread: Sturdy enough to hold everything together without getting soggy but still has that nice chewy interior
  • Unsalted butter: Softened to room temp so it spreads evenly without tearing the bread
  • Provolone cheese: Get the aged stuff if you can find it because it melts into this incredible creamy puddle
  • Salami and pepperoni: The salty fatty foundation that renders down just enough in the pan
  • Shredded iceberg lettuce: Iceberg actually works better here than fancy greens because it stays crunchy
  • Mayo and red wine vinegar: This combo creates that classic sub shop tang without being overwhelming
  • Dried oregano: Do not use fresh here because the dried stuff disperses better through the lettuce mixture
  • Pepperoncini rings: Optional but honestly they make the whole sandwich sing

Instructions

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Make the crunchy lettuce topping:
Toss the shredded lettuce with mayo vinegar oregano salt and pepper until everything is coated evenly
Prep your bread:
Butter one side of each bread slice like you mean it covering every corner to prevent burning
Layer the goods:
Start with provolone on the unbuttered side then pile on salami and pepperoni overlapping them slightly
Add the extras:
Scatter those pepperoncini rings and red onion slices if you are feeling adventurous
Top with lettuce:
Spread the lettuce mixture right on top of the meat layer
Close it up:
Place the remaining bread slices on top buttered side facing out like a sandwich crown
Get your pan ready:
Heat a skillet over medium heat until a drop of water sizzles across the surface
The golden moment:
Cook for about four minutes per side pressing gently with your spatula until everything is melted and perfect
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Easily open jars, bottles, and cans while cooking, making meal prep smoother and less frustrating.
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Two grilled Italian Sub Grilled Cheese sandwiches sit on a white plate, steam rising from the melted provolone and savory meats between toasted bread.  Save
Two grilled Italian Sub Grilled Cheese sandwiches sit on a white plate, steam rising from the melted provolone and savory meats between toasted bread. | dailyhlib.com

Now whenever someone asks what to make for a quick dinner I just gesture toward the deli drawer. This sandwich has saved more weeknights than I care to admit.

Making It Your Own

I have swapped in sharp cheddar when provolone was not available and honestly the extra punch worked beautifully. Sourdough creates this incredible crust that shatters when you bite down while whole wheat keeps it feeling virtuous.

The Skillet Situation

Cast iron gives the most gorgeous even browning but a nonstick pan will absolutely get the job done. Just make sure whatever you use can get and stay hot without any cold spots.

Sides That Actually Work

Kettle chips provide the perfect crunch contrast and something cold on the side helps balance all that warm melted cheese. A simple tomato salad with just salt and olive oil cuts through the richness beautifully.

  • Let the sandwich rest for like two minutes before slicing or the cheese will escape everywhere
  • Cut diagonally because it just tastes better that way I will not debate this
  • Have napkins ready because this is definitely not a neat sandwich situation
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Close-up of an Italian Sub Grilled Cheese, showing melted cheese oozing from grilled bread with bright shredded lettuce and pepperoncini peeking out. Save
Close-up of an Italian Sub Grilled Cheese, showing melted cheese oozing from grilled bread with bright shredded lettuce and pepperoncini peeking out. | dailyhlib.com

There is something deeply satisfying about transforming ordinary sandwich fixings into something that feels like a special occasion.

Recipe FAQs

What type of bread works best for this sandwich?

Italian bread or sturdy white sandwich bread provides the ideal base. For variations, you can substitute whole wheat or sourdough bread, which will add more texture and depth of flavor while maintaining structural integrity during grilling.

How do I prevent the cheese from leaking out while cooking?

Place the cheese directly on the bread before adding the meats, and ensure the lettuce mixture is spread evenly to create a barrier. Cook over medium heat and press gently with your spatula. This technique keeps everything contained while allowing the cheese to melt properly.

Can I make this sandwich vegetarian?

While the traditional version relies on salami and pepperoni for its authentic flavor, you can create a vegetarian version by omitting the cured meats and adding roasted red peppers, sun-dried tomatoes, or sautéed mushrooms for savory depth and texture.

What makes the lettuce topping special?

The lettuce is dressed with mayonnaise, red wine vinegar, and dried oregano, which creates a tangy, herbaceous complement to the rich meats and cheese. This simple dressing adds brightness and prevents the sandwich from feeling too heavy.

How can I add more heat to this sandwich?

Incorporate hot giardiniera or extra pepperoncini rings for a spicy kick. You can also add fresh jalapeños or red pepper flakes to the lettuce mixture. Start with small amounts and adjust to your heat preference.

What side dishes pair well with this sandwich?

Kettle chips or regular potato chips provide a satisfying crunch alongside the grilled sandwich. A simple tomato salad with fresh basil and olive oil offers a lighter, refreshing contrast that balances the richness of the melted cheese and cured meats.

Italian Sub Grilled Cheese

Melty sandwich combining Italian cold cuts, provolone, and dressed lettuce, grilled to golden perfection in just 20 minutes.

Prep time
10 minutes
Time to cook
10 minutes
Total duration
20 minutes
Created by Declan OBrien


Skill level Easy

Cuisine type Italian-American

Makes 2 Number of servings

Dietary info None specified

Needed ingredients

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

How to make it

Step 01

Prepare Lettuce Mixture: In a mixing bowl, combine shredded iceberg lettuce, mayonnaise, red wine vinegar, dried oregano, salt, and freshly ground black pepper. Mix thoroughly until evenly combined. Set aside.

Step 02

Butter the Bread: Lay out all 4 bread slices on a work surface. Spread one side of each slice with softened unsalted butter.

Step 03

Assemble Sandwich Base: Place two buttered bread slices, buttered side down, on a clean work surface. Top each slice with 2 slices of provolone cheese, 3 slices of salami, and 3 slices of pepperoni in layers.

Step 04

Add Optional Toppings: If desired, distribute pepperoncini rings and thinly sliced red onion evenly over the meats and cheese on each sandwich.

Step 05

Add Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats, cheese, and optional toppings on each sandwich.

Step 06

Complete Sandwiches: Top each sandwich with the remaining bread slices, positioning them buttered side up.

Step 07

Grill Sandwiches: Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently with a spatula, until the bread is golden brown and the cheese is fully melted.

Step 08

Finish and Serve: Remove sandwiches from heat using a spatula. Slice each sandwich in half diagonally and serve immediately while hot.

Tools you'll need

  • Large skillet or grill pan
  • Spatula
  • Mixing bowl
  • Sharp knife
  • Cutting board

Allergy details

Look into every ingredient for allergens and check with a doctor if you're unsure.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs from mayonnaise; verify specific brand formulations
  • Contains pork from salami and pepperoni
  • Check all ingredient labels for potential trace allergens

Nutrition details (per serving)

Nutrient details are for reference and aren't a substitute for doctor's advice.
  • Calories: 540
  • Total fat: 34 grams
  • Carbohydrates: 35 grams
  • Proteins: 24 grams